cDNA Synthesis Market Size, Share, Growth, Trends and Industry Analysis, By Type (Oligonucleotide Synthesis, Gene Synthesis), By Application (Academic Institutes, Hospitals, Pharmaceutical & Biotechnology Companies, Research Centers), Regional Insights and Forecast From 2025 to 2033

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cDNA SYNTHESIS MARKET OVERVIEW

The global cDNA synthesis market size was projected at USD 0.08 billion in 2024 and is anticipated to reach USD 0.21 billion by 2033, registering a CAGR of 11.05% during the forecast period from 2025 to 2033.

Complementary DNA synthesis, or cDNA synthesis, is a basic molecular biology procedure in which ribonucleic acid (RNA) is transformed into complementary DNA (deoxyribonucleic acid). Reverse transcriptase is the enzyme that catalyzes the process. The synthesis of cDNA is extensively employed in several scientific domains and holds significance in areas including molecular diagnostics, cloning, functional genomics, and gene expression studies. The creation of cDNA is essential for researching patterns of gene expression. Through RNA-to-cDNA conversion, scientists may examine the concentrations of particular genes in various specimens.

COVID-19 IMPACT

Pandemic Caused Halt in Lab Activities and Research Downgraded the Market Growth

The global COVID-19 pandemic has been unprecedented and staggering, with the market experiencing higher-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden market growth reflected by the rise in CAGR is attributable to market’s growth and demand returning to pre-pandemic levels.

Global supply chains have been disrupted by the pandemic, which has an impact on the manufacture and delivery of consumables and laboratory reagents, including those used in cDNA synthesis kits. Lockdowns, limitations on laboratory access, and the reallocation of resources for COVID-19-related research caused several research programs and activities to be momentarily suspended or postponed. Some labs and businesses turned their attention and resources away from other fields, like as fundamental research involving cDNA synthesis, in favor of COVID-19 research and diagnostics.

LATEST TRENDS

High Throughput Methods and Enhanced Reverse Transcriptase to Enlarge the Market Share

The development of high-throughput technologies has affected the synthesis of cDNA. Workflows have included robots and automated technologies to improve repeatability, decrease hands-on time, and boost throughput. Reverse transcriptase enzyme discovery and improvement for cDNA synthesis have been ongoing trends. For more dependable outcomes, enzymes with enhanced processivity, sensitivity, and fidelity are desired.

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cDNA SYNTHESIS MARKET SEGMENTATION

By Type

Based on type the global market can be categorized into oligonucleotide synthesis, gene synthesis and others.

• Oligonucleotide Synthesis: The chemical process of creating small, single-stranded DNA or RNA molecules, or oligonucleotides, is known as oligonucleotide synthesis. These can be specially crafted sequences created for certain studies or medical applications. Among the many uses of oligonucleotides in molecular biology are as synthetic genes for genetic engineering, probes for hybridization investigations, and primers for polymerase chain reaction (PCR).

• Gene Synthesis: Gene synthesis is the chemical construction of a DNA sequence, usually a gene, in an artificial environment. This procedure creates small DNA segments, or oligos, which are then put together to form a larger sequence. When scientists or biotechnology businesses want a certain DNA sequence for a variety of purposes, such as functional genomics, genetic engineering, or protein expression, they turn to gene synthesis.      

By Application

Based on application the global market can be categorized into academic institutes, hospitals, pharmaceutical & biotechnology companies, research centers and others.

• Academic Institutes: When examining gene expression patterns in diverse tissues, under varied circumstances, or in response to certain stimuli, academic researchers frequently employ cDNA synthesis.

• Hospitals: cDNA synthesis may be used in molecular diagnostic applications in a hospital setting. For instance, the identification of RNA viruses and the assessment of gene expression in patient samples are achieved by the use of cDNA in reverse transcription PCR (RT-PCR).

• Pharmaceutical and Biotechnology Businesses: Businesses in the pharmaceutical and biotechnology domains employ cDNA synthesis to investigate the expression of genes linked to illnesses, pinpoint potential therapeutic targets, and create novel therapeutic interventions.

• Research Centers: Research centers employ cDNA synthesis for basic and practical research, regardless of their focus specific illnesses, biological processes, or multidisciplinary studies. Research centers can work together more easily because to cDNA synthesis, which makes it possible for scientists to exchange and examine gene expression data.

DRIVING FACTORS

Bioprocessing and Biopharmaceutical Applications To Sum Up The Market Share

In genetic engineering and molecular cloning, cDNA synthesis is a critical step for obtaining DNA copies of mRNA, which can be inserted into vectors and used to produce recombinant proteins or modify organisms. In the production of biopharmaceuticals, cDNA synthesis is employed to optimize the expression of recombinant proteins in cell lines used for bioprocessing. Funding from government agencies, private foundations, and other sources for life sciences research has supported the growth of cDNA synthesis applications in academic and research institutions.

Disease Research and Drug Discovery to Advance Up the Market Growth

cDNA synthesis is utilized in medical research to find biomarkers, explore disease causes, and create diagnostic instruments. It is essential to molecular diagnostics, particularly when RNA viruses are being detected. cDNA synthesis is used by the biotechnology and pharmaceutical sectors to investigate the expression of genes linked to illness, find possible targets for drugs, and create new therapeutic medicines.

RESTRAINING FACTOR

Transcriptase Errors and Limited Dynamic Range to Hold Back the Market Growth

Errors can be introduced during the synthesis of cDNA from RNA templates by the enzyme reverse transcriptase. Point mutations, incorrect nucleotide incorporation, and inadequate synthesis are a few examples of these mistakes. There could be a limit to the dynamic range of gene expression that cDNA synthesis can capture. It's possible that genes with high and low expression levels won't be fairly represented in the same experiment. Hence, such factors are expected to hinder the cDNA synthesis(LDT) market growth during the forecast period.

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cDNA SYNTHESIS MARKET REGIONAL INSIGHTS

North America to Dominate the Market owing to Higher Rate of Research and Biotechnological Activities

The market is primarily segregated into North America, Latin America, Europe, Asia Pacific, and the Middle East & Africa.

North America leads the worldwide cDNA synthesis(LDT) market share and accounts for the greatest revenue share due to the region's developed laboratory infrastructure and accessibility to skilled workers. The need for cDNA synthesis is widespread, and its applications are found in many different parts of the world. Worldwide, research centers, hospitals, pharmaceutical and biotechnology firms, academic institutions, and research centers carry out biotechnological and scientific operations involving the synthesis of cDNA.  Numerous well-known research institutes, biotechnology businesses, and pharmaceutical corporations are based in the United States and Canada. There is a high demand for cDNA synthesis products in this region because of the considerable emphasis on biomedical research and innovation.

KEY INDUSTRY PLAYERS

Key Industry Players Shaping the Market through Innovation and Market Expansion

Important industry players have a big impact on the market and are crucial in determining customer preferences and market dynamics. These major firms provide consumers easy access to a vast array of clothing alternatives through their huge retail networks and online platforms. Product adoption has increased as a result of their strong worldwide presence and well-known brand, which has also enhanced consumer trust and loyalty. These industry titans also consistently fund R&D, bringing cutting-edge designs, materials, and clever features to cDNA synthesis(LDT) to meet changing customer demands and preferences. These big businesses' combined efforts have a big impact on the market's future direction and level of competition.

List of Top cDNA Synthesis Companies

• Agilent (U.S.)
• Roche (Switzerland)
• Bioline (Canada)
• Bio-Rad Laboratories (U.S.)
• Thermo Fisher Scientific (U.S.)
• QIAGEN (The Netherlands)
• New England Biolabs (U.K.)
• TATAA Biocenter (Sweden)
• Takara Bio (Japan).

INDUSTRIAL DEVELOPMENT

March 2021: Roche declared its intention to purchase GenMark Diagnostics for a sum of $1.8 billion.The core activities of Genmark Diagnostics will stay in Carlsbad, California, and the company will become a subsidiary under the terms of the deal.With the acquisition of German biotech outfit TIG Molbiol, the company enhanced its molecular diagnostics capabilities, as disclosed in September.

REPORT COVERAGE

The report includes a thorough SWOT analysis and offers predictions for market growth in the future. It explores a broad range of market categories and possible applications that might have an impact on the market's trajectory in the upcoming years, as well as key aspects that contribute to the market's growth. The research provides a comprehensive overview of the market's components and identifies possible growth opportunities by taking into account both historical turning points and present trends.