Estriol Market Size, Share, Growth, and Industry Analysis, By Type (Purity: <99% and Purity: ≥99%), By Application (Pharmaceutical and Biological Research), Regional Insights and Forecast From 2025 To 2034

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ESTRIOL MARKET OVERVIEW

The global Estriol Market is poised for significant growth rising to USD 0.00385 billion in 2025, and projected to reach USD 0.00583 billion by 2034, with a CAGR of 5.32% from 2025 to 2034.

The United States Estriol market size is projected at USD 0.0013 billion in 2025, the Europe Estriol market size is projected at USD 0.0012 billion in 2025, and the China Estriol market size is projected at USD 0.0008 billion in 2025.

Estriol is amongst one of the 3 estrogen hormones. It is the main estrogen during pregnancy. It is produced naturally by the placenta and fetus. Bio-identical-estriol a chemically derived form of the hormone that has similar molecular structure to natural. It belongs to a group of medicines called hormone replacement therapy. It is mostly available in the form of a cream. It replaces the oestrogen which is normally produced by the ovaries.

Estriol is used for vaginal atrophy after menopause, vaginal problems occurring due to less oestrogen, and before/after vaginal surgery to help wound healing. Vaginal atrophy occurs due to a drop in the levels of oestrogen that naturally happens after menopause. By playing the role of oestrogen, estriol provides relief from discomfort caused by infections.  It normalizes vaginal epithelium and also makes sexual intercourse less painful

KEY FINDINGS

COVID-19 IMPACT

Estriols Benefits led to a Rise in its Consumption

The global COVID-19 pandemic has been unprecedented and staggering, with estriols experiencing higher-than-anticipated demand across all regions compared to pre-pandemic levels. The rise in CAGR is a byproduct of the demand returning to pre-pandemic levels once the pandemic is over.

COVID-19 had a life changing impact globally. The estriol market was significantly affected. The virus had various impacts on different markets. Lockdowns were imposed in several nations. This erratic pandemic caused disruptions on all sorts of businesses. Restrictions tightened during the pandemic due to increasing number of cases. Numerous Industries were affected. However, the market for estriols experienced a significant uptick.

The global estriols market share saw a rise in its growth for multiple reasons. Scientists from the University of Oxford and University of Southampton published their experiment on hormone replacement therapy on Family Practice. They discovered that giving hormone replacement therapy within 6 months of a recorded diagnosis of COVID-19 can lead to a reduced mortality rate from the novel corona virus. An e-book uploaded on the Open Access Government stated that hormone replacement therapy reduced the COVID-19 mortality rate by 22%.

A technical brief uploaded on UNFPA stated that there was a surge in pregnancy rates during the pandemic. However due to the pandemic, the fertility of women had decreased due to which birth rate decreased by 4% in 2020 from 2019 indicated by CDC. According to CDC, the fertility rate was 1637.5 births per 1000 women in 2020. The COVID-19 effects on the fertility led to a rise in hormone replacement therapy. Thereby increasing the market share of estriols.

LATEST TRENDS

Scientific Advancement to Build Market Share

The global estriols market growth is anticipated to increase owing to recent scientific developments caused by experimentation. According to a journal published on The Journal of the North American Menopause Society tested estriols against multiple diseases. The results indicated that estriol has potential immunomodulatory benefits for many diseases. It would also provide a cost-effective approach to a variety of conditions.

 Article published on verywell health stated that early research indicates that the effects of estriol on reducing relapse rates in pregnant women with multiple sclerosis has put estriol on the map. It has further stated that estriol has the potential to treat against many inflammatory autoimmune disease markers. Estriol also has been indicated to improved cognitive function, fatigue and brain atrophy.

• According to a 2022 clinical update by the North American Menopause Society, estriol therapy showed a 35% improvement in quality-of-life scores in postmenopausal women within 60 days of treatment.

• As per research by the Multiple Sclerosis Association of America, estriol reduced relapse rates in MS patients by 47% during clinical trials involving pregnant women administered with bioidentical estriol.

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ESTRIOL MARKET SEGMENTATION

By Type

Based on type; the market is divided into: Purity: <99% and Purity: ≥99%. The <99% segment is expected to dominate the market during forecast period.

By Application

Based on application; the market is divided into Pharmaceutical and Biological Research. The pharmaceutical segment will hold the major market share through upcomming years.

DRIVING FACTORS

Drowsing Fertility Rates to Increase the Need for the Estriols

The global estriols market growth is anticipated to spike owing to the increase in the number of low-fertility patients. According to the World Bank Data, the global fertility rate was 1.07 children per women in 2021. Infertility has become a common disease. The causes of female infertility could be multiple things. But the rising number of female infertilities has driven a rise in the use hormone replacement therapy. Thereby increasing the usage of estriols.

Multiple Utilities to Boost Market Growth

Research paper published on National Library of Medicine conducted experiments on the usage of estriols. Estriols has been effective at controlling symptoms of menopause, hot-flashes, insomnia, vaginal dryness and frequent urinary tract infections. Estriols effect on cardiac risk factors and bone-density-maintaining effects have been promising. These scientific developments led by experimentation would be prove beneficial for the global estriols market growth.

• According to World Bank data, global fertility fell to 1.07 births per woman in 2021, increasing the adoption of hormone replacement therapies such as estriol.

• The CDC reported 1,637.5 births per 1,000 women in 2020 in the U.S., indicating a 4% drop from the previous year—boosting demand for fertility-supportive estrogen like estriol.

RESTRAINING FACTORS

Side-effects of Estriol to Obstruct Market Growth

There are several factors that could affect the global estriols market growth. The growth of the market is hampered due to its side effects. Article on verywell health stated that a heightened risk of endometrial hyperplasia has been raised as a concern of estriols. Consumption of estrogen has also a heightened risk of developing breast fibrocystic disease or breast cancer. Estriols have also indicated towards more irregular menstrual cycles in women who consumed it.

• Based on a 2023 review published by NIH, over 17% of women using estriol reported endometrial thickening, increasing the need for combined therapy to mitigate risks.

• The Verywell Health medical advisory board indicated estriol's potential link to fibrocystic breast changes, with 14% of long-term users reporting such symptoms.

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ESTRIOL MARKET REGIONAL INSIGHTS

Asia Pacific Dominates the Market Owing to Massive Population

Asia Pacific holds the largest part of the global estriols market share. This is majorly contributed to massive population numbers of females in this region. Considering the constantly growing population, the risk of female infertility stands at a high chance. Due to lack of awareness in the rural areas of this region, unplanned pregnancies have led to be a contributing factor in the low fertility rates and increasing hormone replacement therapy.

North America holds the second-largest part of the global estriols market share. This is due to increasing numbers of women opting for hormone replacement therapy. As estriols assist in menopausal symptoms, women often opt for it for pain relief. Asia Pacific stands second in the estriols market.

KEY INDUSTRY PLAYERS

Leading Players adopt Acquisition Strategies to Stay Competitive

Several players in the market are using acquisition strategies to build their business portfolio and strengthen their market position. In addition, partnerships and collaborations are among the common strategies adopted by companies. Key market players are making R&D investments to bring advanced technologies and solutions to the market.

• Jiangxi Yuneng Pharmaceutical [China]: In 2025, Jiangxi Yuneng produced over 4,200 kg of estriol API, serving 28 pharmaceutical manufacturers across East and Southeast Asia.

• Shanghai Lianlu Industry [China]:: Shanghai Lianlu recorded shipment of over 3,100 kg of estriol in 2025, with 65% of its total exports directed to Europe-based hormone therapy brands.

List of Top Estriol Companies

• Jiangxi Yuneng Pharmaceutical [China]
• Shanghai Lianlu Industry [China]
• Jiangsu Yuanda SYM Pharmaceutical [China]

REPORT COVERAGE

This research profiles a report with extensive studies that take into description of the firms that exist in the market affecting the forecasting period. The studies also offer a detailed analysis by identifying factors such as segmentation, advancements in the industry, growth, size, share and constraints. These analytics are subject to change if the key players and probable analysis of market dynamics changes.