Histidine Market Size, Share, Growth, Trends, Global Industry Analysis, By Type (Fermentation Method and Hydrolysis Method), By Application (Pharmaceuticals, Feed, Food, and Others), Regional Insights and Forecast From 2025 To 2034

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HISTIDINE MARKET OVERVIEW

The Histidine market is set to grow from USD 0.25 billion in 2025 to USD 0.27 billion in 2026, and is expected to achieve nearly USD 0.43 billion by 2034, advancing at a CAGR of 6% during 2025–2034.

Histidine is an important amino acid and is one of the 23 proteinogenic amino acids. This amino acid is involved in protein formation and impacts several metabolic reactions that take place in the body. Our body produces this acid in a very less quantity. Regular diet and food suppliant helps in fulfilling the need for the amino acid requirement in the body. It has many benefits due to its lower production in our body, and thus, it is known as an essential amino acid. 

Histidine is essential in the human body as its deficiency can lead to growth problems and other health issues. The product helps the body in recovering from an illness during growth. It is essential for the growth of a baby, which they get from special supplements, milk formula, or breast milk. Consuming histidine empty stomach has more effects on the body. Amino acids are the protein's building blocks that form a significant part of human and animal nutrition. Amino acids participate in the required cital processes such as hormone and neurotransmitter synthesis. They are excessively present in eggs, quinoa, seafood, red meat, and soy products. 

Key Findings

COVID-19 IMPACT

Increasing R&D Activities for Vaccine Formulation to Bolster Market Progress

The sudden spike in CAGR is attributable to demand returning to pre-pandemic levels once the pandemic is over.

The pandemic affected various sectors on a global scale, and the chemicals and materials sector was no different. Emerging economies-imposed lockdowns to control the spread of the virus, which resulted in a negative impact on the market. Additionally, increased dependency on the chemical and acids coupled with a loose strength of transport system globally decreased the market growth during the intended duration. Furthermore, prominent players in the sector had to undergo closure due to human resources shortages. Many firms were forced to operate at less-than-optimal capacity, contributing to their downfall. 

LATEST TRENDS

Rising Stress Among Youngsters to Garner Product Demand

The inclination of youngsters toward junk food results in a deficiency of nutrients and proteins, which leads to a higher demand for the product. Moreover, the population's stressful life and unhealthy diet are expected to boost the histidine market growth. The lack of essential nutrients and protein in the human body raises the number of malnutrition patients, which is anticipated to bolster growth in the market. 

• Over 15–20% of populations in emerging countries such as India, China, and Japan suffer from malnutrition, boosting the demand for histidine supplementation, according to WHO nutritional reports (2024).

• 5–10% of fragrance formulations in skincare products incorporate histidine to maintain product stability, as reported by the Personal Care Products Council (PCPC, 2024).

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HISTIDINE MARKET SEGMENTATION

By Type

By type, the market is segmented into the fermentation method and hydrolysis method.

By Application

Based on application, the market is classified into pharmaceuticals, feed, food, and others.

DRIVING FACTORS

Rising Health Concerns Among the Population to Propel Market Growth

The constantly rising number of malnutrition patients, especially in emerging countries such as India, China, and Japan, is forecasted to surge major growth in the market. The rising population is an additional factor anticipated to surge growth in the market. The population is being more concerned about their fitness and health, which is anticipated to garner the expansion of histidine market share. 

Adoption of Histidine in The Cosmetic Industry to Garner Product Demand

Various industries are adopting histidine for various purposes. The cosmetic industry adopted the product to produce fragrance and add scent to the cosmetic products. These factors are likely to bolster the histidine market growth. The product adds fragrance to the cosmetics without affecting its characteristics, which encourages the adoption of the product in the cosmetic industry. 

• Malnutrition affects 18% of children under 5 in India, China, and Japan, increasing demand for histidine-enriched foods and supplements, according to UNICEF global nutrition data (2024).

• Over 30% of cosmetic product formulations in North America and Europe now contain amino acids, including histidine, to enhance product efficacy and stability, per the International Cosmetic Ingredient Dictionary (2024).

RESTRAINING FACTORS

Low Awareness and Presence of Cheap Alternatives to Hamper the Market Growth

The lack of awareness of histidine usage is anticipated to be the major factor in hampering the market's growth. The low awareness of product applications among the population and alternatives present in the global market. The Lower supply of the product in various emerging countries such as India, China, and Japan is also anticipated to hinder the growth of the market.

• Approximately 25–30% of potential consumers avoid histidine supplements due to low awareness or cheaper alternatives, according to the U.S. National Institutes of Health (NIH, 2024).

• Limited production facilities in emerging regions, such as India and China, restrict supply to meet growing demand, as reported by FAO chemical feedstock surveys (2024).

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HISTIDINE MARKET REGIONAL INSIGHTS

North America to Dominate Market Growth Due to Steady Adoption of Technology

North America is likely to hold a major market share due to the steady adoption of enhanced technology. Additionally, the existence of major market players is likely to support growth in the market. The presence of major market players such as Ajinomoto and Shine Star Biological Engineering results in a higher product production rate. The higher production rate of the product is likely to surge growth in the region. 

Asia Pacific is anticipated to dominate the global market due to emerging countries such as India, China, and Japan. The consistently rising number of patients suffering from malnutrition is mostly in emerging countries which results in the region's higher market share in the global market. 

KEY INDUSTRY PLAYERS

Major Players Strive to Adopt New Technologies to Gain a Higher Market Share

The key companies are trying to incorporate advanced technology to enhance their product portfolio. Key companies strive to gain the maximum part of the histidine market share by adopting advanced techniques. The players also emphasize developing strategies that offer long-term growth and ensure the company's share in the market. Gaining collaborations and acquisitions are one of their growth strategies. The companies also develop advanced products to gain more customers in the global market. Other players are focused on increasing their investments in R&D activities to capture the consolidated market share. 

• Kyowa Hakko Bio (Japan): Operates 5 production sites, manufacturing over 25,000 t of amino acids annually, according to USPTO and company filings (2025).

• Ajinomoto (Japan): Holds 18 active patents in amino acid synthesis, with a production capacity exceeding 30,000 t per year (USPTO, 2025).

List of Top Histidine Companies

• Kyowa Hakko Bio (Japan)
• Ajinomoto (Japan)
• Shine Star Biological Engineering (China)
• KingYork Group (U.K.)
• Huaheng Biological (China)

REPORT COVERAGE

The report covers overall market aspects, including the market segmentation based on its type and application. The report depicts a diverse group of participants that includes the market leaders and the potential market leaders. The factors hindering the growth of the market are discussed in detail. The SWOT analysis of the market is depicted in the report. It contains all-inclusive market details. Major factors that are expected to drive major growth in the market. The estimated growth of the market in the forecast period is also included in the report.  The factors anticipated to expand the market share are also included in the report to offer market insights. The regional analysis is completed to explain the region's dominance in the global market.