NK Cell Therapy Market Size, Share, Growth, And Global Industry Analysis by Type (NK Cell Therapies, NK Cell Directed Antibodies) by Application (Cancer, Gastrointestinal Diseases, Others), Covid-19 Impact, Latest Trends, Segmentation, Driving Factors, Restraining Factors, Key Industry Players, Regional Insights, and Forecast To 2031

Updated On: 08 April 2024

NK Cell Therapy Market Report Overview

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The global NK cell therapy market size was USD 347.8 million in 2021 and is expected to reach USD 1579.5 million by 2031, exhibiting a CAGR of 16.2% during the forecast period.

Natural killer (NK) cells are a subset of immune effector cells that play an important role in immune activation against aberrant cells. Unlike T cell activation, NK cell activation is mediated by the contact of NK receptors with target cells, which is independent of antigen processing and presentation. Because of their relatively simple activation cues, NK cells have received a lot of attention in the field of cancer immunotherapy. There are numerous attempts underway to create and design NK cell-based cancer immunotherapy. We examine the advances, problems, and future views of NK cell biology in this review, as well as continuing pre-clinical and clinical research of NK cell-based therapeutics.

Several techniques, such as ex vivo pre-conditioning with cytokines or small molecular medicines and creating a chimeric antigen receptor (CAR) NK, have been developed to improve the efficacy of NK cell therapies. Furthermore, researchers are working to maximize the therapeutic effects of allogeneic NK cells through robust proliferation, improved targeting, and prolonged persistence of potent immune cells. This can also help to launch a powerful and long-lasting anti-cancer immune-mediated onslaught.

COVID-19 Impact: Pandemic Paused The Research And Development Of Treatment Causing Detrimental Influence On The NK Cell Therapy Market

The global COVID-19 pandemic has been unprecedented and staggering, with the NK cell therapy market experiencing higher-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden rise in CAGR is attributable to the NK cell therapy market growth and demand returning to pre-pandemic levels once the pandemic is over.

Due to COVID-19, governments around the world-imposed lockdowns, stifling research and clinical development of NK cell treatments. This condition persisted until Q2 2021, having a detrimental influence on the worldwide NK cell therapy market and resulting in a decrease in preclinical and clinical studies of product candidates. The main cause has been the difficulty in recruiting patients for ongoing clinical trials, which will have an influence on drug launch timeframes. However, it is worth noting that with the relaxation of restrictions beginning in Q2 2021, the market for NK cell therapy has acquired substantial traction and is expected to rise throughout the projected period 2024-2032. The COVID-19 pandemic has put a significant pressure on NK cell therapeutic research and development. Companies involved in NK cell therapies have shifted their focus to the research and development of medications used for COVID-19 treatment in order to assist governments and communities throughout the world in establishing a new normal. As a result of a shift in priorities caused by the COVID-19 pandemic, the rollout of developing medicines has been postponed. Furthermore, pharmaceutical companies are redirecting financial resources to create and repurpose existing pharmacological compounds for COVID-19 prevention and therapy. Most pharmaceutical companies have embraced this technique in order to gain significant money from the sale of COVID-19 medications. These factors interact to influence the development and commercialization of new NK treatments.

Latest Trends

"Development In Tumor-Targeted Antibody Methods Boosting The NK Cell Therapeutic Market Growth "

One of the key factors driving NK cell therapy market expansion is an increase in the number of people suffering from cancer, infectious diseases, and liver ailments. This can be related to poor eating habits, a lack of physical activity, rising air pollution, and an increase in the number of people consuming alcohol and tobacco products. Moreover, the number of clinical research focusing on tumor-targeted antibody methods to improve the therapeutic efficacy of NK-cell-based therapy while limiting risks and toxicities is increasing. Furthermore, various countries' governing bodies are sponsoring financial plans for cancer patients, offering a positive picture for the market. 

NK Cell Therapy Market Segmentation

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• By Type Analysis

According to type, the market can be segmented into NK cell therapies, NK cell directed antibodies. NK cell therapies’ is the leading segment by type analysis.

• By Application Analysis

Based on application, the market can be divided into cancer, gastrointestinal diseases, others. Cancer is the leading segment by application analysis.

Driving Factors

"Increase In Chronic Disorders Driving The Market Upwards"

Chronic disorders, such as heart disease, arthritis, diabetes, stroke, or cancer, are more common in older persons and can be managed but not cured. Chronic diseases are a major concern in global healthcare. Changes in lifestyle and physical inactivity, bad nutrition, and cigarette use all contribute to an increase in the global burden of chronic diseases.

Furthermore, as the risk of contracting cancer increases with age, the growing geriatric population around the world is functioning as another growth-inducing factor, stimulating demand for NK cell treatments. Aside from that, because cancer patients' immune responses are inadequate, health businesses are exploring novel ways and technology to increase immune responses using allogeneic, off-the-shelf NK cell-based therapies.

"Growing Application in Chronic Diseases to Boost Growth "

An increasing number of chronic disease patients prompted scientists and researchers to develop a new innovative therapeutic approach to provide patients with the best curative treatment option, which can be accomplished by using natural killer (NK) cell therapy, which has the potential to generate a strong immune response as well as anti-tumor capability. Because cancer is a severe disease and current treatment methods may cause tumour recurrence, the need for the optimal therapeutic approach is growing by the day. Immunotherapies have received a lot of interest in recent years for treating various cancers. CAR-T cell therapies have been explored and employed among immune-therapies; however, they have significant disadvantages that have led to the creation of natural killer (NK) cell therapies. Because a medicine based on the natural killer (NK) cell therapy method has not yet been licensed, it is necessary to enhance public awareness. This is why a number of organizations and market participants are undertaking a campaign to raise awareness about natural killer (NK) cell therapy.

Restraining Factors

"Lack Of Selectivity And Poor In-Vivo Survival Of Natural Killer Restricts The Market Growth"

The lack of selectivity and poor in-vivo survival of natural killer (NK) cells provide a challenge to market manufacturers. Because NK cells lack specificity, they attack the wrong cells, resulting in poor treatment. Natural killer cell lack of specificity and low in-vivo survival decreases the therapeutic impact of NK cell therapy. Such a problem undermines the credibility of the medicine employed in clinical trials and presents hurdles to manufacturers seeking approval.

NK Cell Therapy Market Regional Insights

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"Technological Advancements Growing The Market Share And Revenue In North America"

North America will continue to dominate the NK cell therapeutics market in terms of market share and revenue during the forecast period due to technological advancements and an increasing number of research and development activities for the prevention of chronic diseases in this region to generate novel formulation.

The Asia Pacific area is expected to expand at the fastest rate over the forecast period of 2022-2028, owing to an increase in the number of government programs to raise awareness and the region's rising cancer prevalence.

Key Industry Players

"Key Players Focus on Partnerships to Gain a Competitive Advantage "

Prominent market players are making collaborative efforts by partnering with other companies to stay ahead of the competition. Many companies are also investing in new product launches to expand their product portfolio. Mergers and acquisitions are also among the key strategies used by players to expand their product portfolios.

List of Market Players Profiled

• Nektar Therapeutics (U.S.)
• Innate Pharma SA (France)
• Affimed (Germany)
• Chipscreen Biosciences (China)
• Fate Therapeutics (U.S.)
• Glycostem Therapeutics (Netherlands)
• Dragonfly Therapeutics (U.S.)
• Kiadis Pharma (Netherlands)
• NantWorks (U.S.)
• Nkarta Therapeutics (U.S.)
• Fortress Biotech (U.S.)

Report Coverage

This research profiles a report with extensive studies that take into description the firms that exist in the market affecting the forecasting period. With detailed studies done, it also offers a comprehensive analysis by inspecting the factors like segmentation, opportunities, industrial developments, trends, growth, size, share, and restraints. This analysis is subject to alteration if the key players and probable analysis of market dynamics change.