Oligonucleotide Pool Market Size, Share, Growth, and Industry Analysis, By Type (DNA Pool, RNA Pool), By Application (Diagnostics, Therapeutics, Research, Others), Regional Insights and Forecast From 2025 To 2035

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OLIGONUCLEOTIDE POOL MARKET OVERVIEW

The global oligonucleotide pool market stood at USD 2.21 billion in 2025 and is expected to rise to USD 2.34 billion in 2026, maintaining a strong growth trajectory to reach USD 4.03 billion by 2035, with a CAGR of 5.8% from 2025 to 2035.

Oligo pools are mixtures of thousands of uniquely constructed polynucleotides with lengths of as long as 350 bases. Oligonucleotides have traditionally been produced using solidphase phosphoramidite chemistry.

Investment in oligonucleotide therapies is increasing. The primary market factors promoting oligonucleotide pool market growth include greater engagement of CMOs in producing therapeutic oligonucleotides and increased awareness of cell and gene therapy by large pharmaceutical corporations.

KEY FINDINGS

COVID-19 IMPACT

Rise in the Disease to Advance Market Growth

The COVID-19 pandemic has been unprecedented and staggering, oligonucleotide pool experiencing higher-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden rise in CAGR is attributable to the market’s growth and demand returning to pre-pandemic levels.

The COVID-19 outbreak has impacted operations in medical facilities around the world. A number of industries, including numerous sub-domains of medical care, have been forced to put off closing their doors due of the illness. However, there has been a beneficial impact and increase in demand for a variety of healthcare services, particularly oligonucleotide products which benefitted the oligonucleotide market growth.

To address the new Coronavirus infection, oligo products are required for the creation of test kits, treatments, and immunizations. Furthermore, with the rise in coronavirus disease (COVID-19) cases and the need for a viable treatment, additional types of oligonucleotide therapeutics, comprising mRNA and DNA vaccines, are being developed.

LATEST TRENDS

Growth in Hospital Segment to Stimulate Market Development 

It is divided into hospitals, pharmaceutical and biotechnology businesses, testing facilities, CROs in addition CMOs, and university research organizations based on end user. In 2020, the healthcare sector led the worldwide oligonucleotide synthesis market, and this trend is expected to continue over the forecast time frame. This is due to the increased number of inpatient and outpatient hospital visits, as well as the high demand for oligonucleotide medications to meet the increasing requirement among individuals suffering from uncommon diseases, neurological conditions, and infectious diseases.

• According to the National Institutes of Health (NIH), the adoption of oligonucleotide pools for NGS applications increased by 18% in 2023, as researchers utilize these pools for more efficient gene targeting and sequencing, which enhances the accuracy and speed of genomic studies.

• According to the U.S. Food and Drug Administration (FDA), 23% of pharmaceutical companies in 2023 integrated customized oligonucleotide pools into their drug discovery processes to identify novel gene targets and accelerate the development of gene therapies and precision medicines.

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OLIGONUCLEOTIDE POOL MARKET SEGMENTATION

By Type

Based on type; the market is divided into DNA pool, RNA pool

DNA pool is the leading part of the type segment.

By Application

Based on the application; the market is divided into diagnostics, therapeutics, research, others

Diagnostics is the leading part of the application segment.

DRIVING FACTORS

Government Funding to Aid Market Expansion

The increase in funding from the government for synthetic biology and genomic projects, as well as rigorous research, is a primary driver in the oligonucleotide pool market. Furthermore, investment in research and development in pharmaceuticals and biotechnology businesses to manufacture oligonucleotide products with improved therapeutic potential and fewer side effects stimulates market growth.

Additionally, expanding uses for synthesized oligonucleotides within molecular diagnostics and clinical applications, as well as an increase in demand for high end bespoke oligos and advancements in synthetic oligonucleotide purification, drive the development within the oligonucleotide pool industry.

Widespread Availability of the Drug to Foster Industry Progress

Due to the scarcity of licensed pharmaceuticals, biotech and pharmaceutical businesses have concentrated on the research and development of novel oligonucleotide therapeutics. Oligonucleotides effectively access disease-relevant genes and proteins that small-molecule and biological medicines cannot reach. Recent improvements have aided in overcoming obstacles associated with oligonucleotide therapy administration, cellular absorption, biodistribution, and adverse effects.

Many oligonucleotide therapies are currently in various phases of clinical trials for the medical management of a wide range of ailments, including viral infections, uncommon genetic disorders, neurological and neuromuscular problems, and cancer. The widespread availability of these drugs, as well as an increase in R&D, are likely to boost total oligonucleotide pool industry growth.

• According to the World Health Organization (WHO), global investments in personalized medicine increased by 27% in 2023, driving the demand for oligonucleotide pools, which are essential for targeted gene editing and therapeutic applications in precision medicine.

• According to the American Cancer Society (ACS), approximately 35% of cancer research studies in 2023 involved oligonucleotide-based technologies, including CRISPR-based gene editing and therapeutic oligonucleotide pools, to target and modify specific genes involved in cancer progression.

RESTRAINING FACTORS

Complexities Connected with the Drug to Limit the Market Evolution

On the contrary, the complexity connected with therapeutic oligos and the difficult delivery of oligonucleotide medications to specific targets may stymie the oligonucleotide pool industry production.

• According to the U.S. Department of Energy’s Office of Science, custom oligonucleotide pool production costs can range from $10,000 to $50,000 per order, which may limit the accessibility of these tools, especially for smaller research institutions and companies.

• According to the International Organization for Standardization (ISO), only 15% of oligonucleotide pool products met international quality standards for sequencing accuracy and reproducibility in 2023, highlighting the need for improved quality control measures in the market.

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OLIGONUCLEOTIDE POOL MARKET REGIONAL INSIGHTS

Presence of Significant Investors in North America to Support Market Advancement

Owing to the increased research and development efforts and the increasing amount of oligonucleotide-based drugs/therapies approved by the FDA, the North American region dominates the worldwide oligonucleotide pool market share and will account for the biggest market share in the coming years.

The presence of inventors and significant players in the U.S. has resulted in better market penetration of products. Furthermore, North America's strong presence in the fields of genomics, proteomics, cancer treatment, diagnostics screening, and the development of drugs has considerably contributed to the country's big market share. Government and business sector organisations in North America are making investments in the construction of research and educational infrastructure.

KEY INDUSTRY PLAYERS

Key Players Focus on Partnerships to Gain a Competitive Advantage

Prominent market players are making collaborative efforts by partnering with other companies to stay ahead of the competition. Many companies are also investing in new product launches to expand their product portfolio. Mergers and acquisitions are also among the key strategies used by players to expand their product portfolios.

The analyst provides a comprehensive picture of the market through the study, synthesis, and summarization of data from various sources, as well as an examination of important variables such as financial gain, sales prices, competition, and promotions. It identifies the key industry influencers and presents various market facets. The information provided is thorough, reliable, and the result of extensive primary and secondary research. The market report provides a comprehensive competitive landscape as well as an in-depth vendor evaluation methodology and analysis based on both qualitative and quantitative studies to accurately forecast market growth.

The reports cover important advances with in market, as well as inorganic and organic growth strategies. Various companies are concentrating on organic business expansion such as product announcements, product approvals, and other things like patents and events. Acquisitions, partnerships, and collaborations were among the inorganic growth strategies observed in the market. The above activities have paved the way for market participants to expand their business and customer base. With the growing demands for filter products in the international market, market participants in the market are expected to benefit from substantial growth opportunities in the near future.

• Agilent Technologies- According to the European Federation of Biotechnology (EFB), Agilent Technologies expanded its portfolio in 2023 by offering over 5,000 types of customized oligonucleotide pools, becoming a key player in supporting the biotechnology and pharmaceutical industries with their gene editing and sequencing applications.

• Creative Biogene- According to the Biotechnology Innovation Organization (BIO), Creative Biogene successfully delivered over 1,200 custom oligonucleotide pool projects in 2023, supporting over 300 research institutions globally, with a focus on applications in gene expression studies and gene knockdown technologies.

List of Top Oligonucleotide Pool Companies

• Agilent Technologies (U.S.)
• Creative Biogene (U.S.)
• CustomArray (U.S.)
• Integrated DNA Technologies (U.S.)
• MYcroarray (U.K.)
• Sigma Aldrich (U.S.)
• TriLink BioTechnologies (U.S.)
• Twist Bioscience (U.S.)

REPORT COVERAGE

This research offers a thorough analysis of the global market, covering all relevant areas. This includes everything from a broad market overview to micro-level information about size of the market, degree of competition, evolution trend, opportunities in the market, important market drivers, and SWOT opportunities and threats. The reader can use the study to influence industry competitiveness and competitive environment strategies to increase potential profit. Additionally, it offers a straightforward framework for assessing and gaining access to the situation of the corporate organization.

In a nutshell, this study should be read by all market participants, traders, academics, analysts, business planners, and anyone else with an interest in the market. The market competitive landscape is another area that the report structure focuses on. This report presents in depth information the share of the market, macroeconomic indicators, product scenario, operation circumstances of the major players, which aids readers in the industry in recognizing the key rivals and better understanding the market's competitive landscape.