Oligonucleotide Therapy Market Report Overview
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The global oligonucleotide therapy market size was USD 4344.6 million in 2022 and is projected to touch USD 17017 million by 2031, at CAGR of 16.4% during the forecast period.
The COVID-19 pandemic has been unprecedented and staggering, with the Oligonucleotide Therapy market experiencing higher/lower-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden rise in CAGR is attributable to the market’s growth and demand returning to pre-pandemic levels.
A brief, artificial molecule made up of two or more nucleotides is known as an oligonucleotide. These synthetic molecules are used to create medications called oligonucleotide therapies, which work by interfering with the activity of particular genes to cure illness. The significance of oligonucleotide therapies lies in their capacity to target certain genes and alter their activity, making them potentially effective medicines for a range of disorders. Different from traditional medication, oligonucleotide therapies are known to suppress the expression of certain genes. Innovative novel oligonucleotides have been created in recent years that can target particular genes and treat chronic disorders. The chemical synthesis of relatively small nucleic acid fragments with a known chemical structure (sequence) is known as oligonucleotide synthesis. The method is quite helpful in modern laboratory practice since it gives quick, low-cost access to oligonucleotides manufactured to order with the necessary sequence. It is also helpful for making molecular diagnoses for a number of disorders, including cancer diagnosis and the detection of infectious diseases including hepatitis and SARS-COV2.
Due to the rising prevalence of this type of problem, it is projected that the application segment for neuromuscular diseases would develop at the fastest rate. The effectiveness of oligonucleotide medications in the treatment of various disorders has been established. Using oligonucleotides for gene therapy is also becoming more and more common since it gives a more focused strategy without some of the negative effects of conventional chemotherapy.
COVID-19 Impact: Rapid Demand from Healthcare Sector to Boost Product Adoption
The COVID-19 crisis and the production of the first approved mRNA vaccination have made it clear how effective RNA-based therapeutic techniques are for developing new medications. Antisense oligonucleotides (ASOs) are a novel and very promising family of RNA-targeted medicines, in addition to RNA vaccines. A tiny number of drugs have just recently received approval from the Food and Drug Administration. Businesses worldwide are researching novel medicines for COVID-19 patients with acute respiratory symptoms using antisense oligonucleotide therapeutics that may be adjusted for future disease outbreaks. In recent years, tremendous progress has been achieved in both antisense RNA research and antisense RNA implementation. However, the many processes of antisense RNA are still poorly understood. More time and money must be invested in creating medications that block antisense RNA's role in gene regulation in order to treat COVID-19.
Latest Trends
"Positive Clinical Trial Results could Offer Profitable market Growth "
Different antisense treatment solutions are now being actively developed by a number of pharmaceutical firms and ASO technology providers. The majority of research in this field focuses on improving the toxicity profiles, target affinities, nuclease resistance, and cell targeting properties of antisense oligonucleotide candidates. Antisense oligonucleotide treatments have also attracted the attention of several significant pharmaceutical corporations, who are investing time and resources in this field. Partnership activity in the sector has significantly increased during the last few years. Public and private sector investors and investment funds have also shown an interest in the business operations in this industry and have contributed money to the projects of skilled developer firms. Antisense oligonucleotide therapies market is predicted to enjoy significant increase, driven by positive clinical trial outcomes, as multiple late stage treatment candidates are licensed and commercialized over the next ten years. Due to factors like the rising prevalence of chronic and rare diseases, the growing use of oligonucleotides in drug development, and the increase in product launches, the therapeutics segment is anticipated to experience significant growth in the oligonucleotide synthesis market over the forecast period.
Oligonucleotide Therapy Market Segmentation
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- By Type Analysis
According to type, the market can be segmented into antisense oligonucleotide, aptamer, others. Antisense oligonucleotide is anticipated to be the leading segment.
- By Application Analysis
Based on application, the market can be divided into infectious diseases, oncology, neurodegenerative disorders, cardiovascular diseases, kidney diseases, others. Infectious diseases will be the dominating segment.
Driving Factors
"CRISPR's Development is Driving Market Growth"
The revolution sparked by CRISPR-Cas genome editing technology has had an impact on the area of biomedical science. Since antisense RNA therapies have the potential to be employed for immunotherapy, personalized medicine, genetic, infectious, and chronic disease treatment, they will definitely continue to be developed for many years to come. Undoubtedly, there is significant advancement being made in the field of antisense RNA treatments at the moment.
"Increasing Cancer Rates Will Accelerate Market Growth"
Antisense oligonucleotides are currently advised for the treatment of cancer on a larger scale. Despite barriers including an undetermined method of action and customized administration for therapeutic uses, antisense oligonucleotides are becoming anticancer medications. The performance of these molecules in clinical trials is projected to be improved by current research into a range of chemical modifications that provide these nucleotides enhanced capabilities.
Restraining Factors
Market expansion is anticipated to be hampered by the inability to identify small antibodies. In addition, over the forecast period of 2022–2029, strict regulations are anticipated to pose a challenge to the oligonucleotide therapeutics market. Ribose or deoxyribose sugar phosphate serves as the base in natural oligonucleotides, which the nucleus of the body swiftly breaks down. Additionally, oligo-degradation might impact cell growth and proliferation during generic testing. A major obstacle to the use of microarray technology for oligonucleotide synthesis is the poor quality of the oligonucleotide sequence created by microarrays. These elements are anticipated to limit the expansion of the worldwide oligonucleotide synthesis market.
Oligonucleotide Therapy Market Regional Insights
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"North America is anticipated to be the leading region during forecast period"
In terms of revenue share, North America led the world market in 2018. This dominance is partly explained by the existence of a sizable number of clinical trial participants and their attempts to have new treatments approved. By 2030, it is anticipated that one of the factors contributing to its greatest revenue share would also be the high adoption rate for innovative therapies. During the anticipated timeframe, Europe is anticipated to have tremendous growth. Patients with neuromuscular disorders and ATTR, two of the most prevalent uses for antisense oligonucleotides, are becoming more prevalent in this region. The existence of big firms like Roche and Novartis, among others, contributes to the growing demand from these areas.
Key Industry Players
"Key Players Focus on Partnerships to Gain a Competitive Advantage "
Prominent market players are making collaborative efforts by partnering with other companies to stay ahead of the competition. Many companies are also investing in new product launches to expand their product portfolio. Mergers and acquisitions are also among the key strategies used by players to expand their product portfolios.
List of Market Players Profiled
- Alnylam Pharmaceuticals Inc. (U.S.)
- Biogen (U.S.)
- Dynavax Technologies Corp. (U.S.)
- Merck and Co. (U.S.)
- Miragen Therapeuutics Inc. (U.S.)
- Sarepta Therapeutics Inc. (U.S.)
- GlaxoSmithKline (U.K.)
- Pfizer (U.S.)
- Gilead Sciences (U.S.)
Report Coverage
This research profiles a report with extensive studies that take into description the firms that exist in the market affecting the forecasting period. With detailed studies done, it also offers a comprehensive analysis by inspecting the factors like segmentation, opportunities, industrial developments, trends, growth, size, share, and restraints. This analysis is subject to alteration if the key players and probable analysis of market dynamics change.
REPORT COVERAGE | DETAILS |
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Market Size Value In |
US$ 4344.6 Million in 2022 |
Market Size Value By |
US$ 17017 Million by 2031 |
Growth Rate |
CAGR of 16.4% from 2022 to 2031 |
Forecast Period |
2024-2031 |
Base Year |
2023 |
Historical Data Available |
Yes |
Regional Scope |
Global |
Segments Covered |
Type and Application |
Frequently Asked Questions
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What value is the Oligonucleotide Therapy market expected to touch by 2031?
Based on our research the Oligonucleotide Therapy market is expected to reach USD 17017 million by 2031.
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What CAGR is the Oligonucleotide Therapy market expected to exhibit by 2031?
The Oligonucleotide Therapy market is expected to exhibit a CAGR of 16.4% by 2031.
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Which are the driving factors of the Oligonucleotide Therapy market?
Evolving consumer preferences and increased consumption of processed and convenience foods are two main driving factors of the Oligonucleotide Therapy market.
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Which are the top companies operating in the Oligonucleotide Therapy market?
The top key players in the Oligonucleotide Therapy market are Alnylam Pharmaceuticals Inc., Biogen, Dynavax Technologies Corp., Merck and Co., Miragen Therapeuutics Inc., Sarepta Therapeutics Inc., GlaxoSmithKline, Pfizer, Gilead Sciences.