Overt Hepatic Encephalopathy Market Size, Share, Growth and Industry Analysis by Type (Type A (Acute Liver Failure), Type B (Portal Systemic Bypass Without Liver Disease), And, Type C (Liver Cirrhosis)) By Application (Hospitals, Research Institutes, Clinics, And, Others), Regional Insights, and Forecast To 2033

Last Updated: 14 July 2025
SKU ID: 21296841

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OVERT HEPATIC ENCEPHALOPATHY MARKET OVERVIEW

Global overt hepatic encephalopathy market size was USD 0.05 Billion in 2024 and market is projected to touch USD 0.11 Billion by 2033, exhibiting a CAGR of 6.4% during the forecast period.

Hepatic encephalopathy is a very serious neurological disease that happens mainly due to liver damage or liver failure. This can in turn affect the brain as well because when the liver stops functioning it stops removing the toxins from our body which can be highly harmful to the brain. It can lead to various problems such as difficulty in speaking, writing, disorientation and many more.

Along with administering patients with drugs and medicines new non-pharmacological interventions are being used to treat this disorder. Increasing alcohol consumption, smoking, and rising awareness regarding overt hepatic encephalopathy will have a positive impact on the market. All of these factors have contributed in the development and growth of the overt hepatic encephalopathy market share.

COVID-19 IMPACT

Diversion of Resources in Treating COVID-19 Reduced Market Growth

The pandemic of COVID-19 resulted in the downfall of all the markets. The economy of all the countries declined because of the various unfavourable factors that were created by the outbreak of coronavirus. The pandemic of COVID-19 was one of the most severe health crisis which was encountered by the whole world.

Death rates increased rapidly in all the nations. Finding cure for COVID-19 became the need of the hour. All the hospitals and clinics had to give their complete attention in treating the patients affected by coronavirus. Therefore, this reduced the access patients had for hepatic encephalopathy treatment. Delayed diagnosis and treatments for these diseases during the pandemic reduced the market share.

LATEST TRENDS

Incorporation of Non-pharmacological Interventions to Increase Market Growth

There are many new developments that keep on happening in the health industry. One such noticeable development in the overt hepatic encephalopathy market is the incorporation of non-pharmacological interventions to find cure for this condition. Some of these interventions include dietary modifications, and the usage of probiotics to treat this liver disorder.

Along with this several effective medications have also been introduced in the market. The new medicines that have been discovered are aiming to initiate different mechanism of action in both the liver as well as the brain in order to improve the condition of the patient suffering with hepatic encephalopathy. Imaging techniques, and biomarkers are also used for treating this disorder. Patient-centered care is being provided according to the needs and requirements of the individuals. All of these are considered as the latest trend in the market.

Overt-Hepatic-Encephalopathy-Market-Share,-By-Application

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OVERT HEPATIC ENCEPHALOPATHY MARKET SEGMENTATION

By Type

The market can be divided on the basis of type into the following segments:

Type A (acute liver failure), Type B (portal systemic bypass without liver disease), and, Type C (liver cirrhosis). The Type A (acute liver failure) segment is anticipated to dominate the market during the forecast period.

By Application

Classification based on application into the following segment:

Hospitals, research institutes, clinics, and, others. The hospitals segment is predicted to dominate the market during the research period.

DRIVING FACTORS

Increasing Prevalence of Liver Disorder Among Today’s Population to Accelerate Market Growth

One of the major factors that is fueling the market growth is the rising prevalence of liver disorders among people. One of the most commonly found liver disease among people is cirrhosis. This can be considered as a major risk factor when it comes to the occurrence of hepatic encephalopathy. Increase in the elder population is also contributing to the market growth.

Most of the old people are susceptible to overt hepatic encephalopathy and other related complications. Liver disorders happen mainly due to the excess consumption of alcoholic substance and smoking. Consumption of alcohol, and excess smoking has become a very common phenomenon among young adults. They are considered as a form of relieving stress. Continuous consumption of alcohol can lead to the formation of non-alcoholic fatty liver disease (NAFLD). All of these factors are increasing the demand for overt hepatic encephalopathy market.

Increasing Awareness Among People Regarding this Health Condition to Propel Market Growth

With the increasing of hepatic encephalopathy, people are becoming more aware of this condition and the treatments that are available for this condition. Both the patients as well as the healthcare providers are getting educated on the symptoms, diagnosis, as well as cure for liver disorders. This has helped the healthcare experts identify and treat many cases.  

Associations such as the US Food and Drug Administration (FDA) are taking up initiatives to find a better cure for hepatic encephalopathy. This regulatory body is granting permission for the manufacturing of new drugs. This has allowed the researchers to find out effective drugs for complicated liver conditions. Several countries are investing profoundly on research studies and clinical trial to expand the understanding of both doctors and patients about this condition. All of the above-mentioned factors have helped in finding out effective treatments and are thus increasing the overt hepatic encephalopathy market growth.

RESTRAINING FACTORS

High Cost of Treatment for Hepatic Encephalopathy to Decrease Market Growth

One of the major disadvantages that is associated with the market is high cost of treatment. Over hepatic conditions are highly complex in nature and they require critical care as well as treatment. High cost of these treatments can become a burden on the patients and not all of them can afford the treatment. This can act as a limiting factor in the market.

Along with this many people are not aware about the liver disorders. Lack of awareness can result in delayed diagnosis which can eventually lead to failure of treatments and finally death. Limited availability of treatment options for people coming from low economic background can be yet another factor that can hamper the market growth and development.

OVERT HEPATIC ENCEPHALOPATHY MARKET REGIONAL INSIGHTS

North America to Dominate Market Share in Upcoming Years

The North American Region is expected to take over the market in terms of revenue and investments in the coming years. This is due to the prevalence of many favorable factors in this region.  Many people here suffer from liver disorders. Majority of the population here consists of aged people who are more prone to get infected by liver diseases.

North America is a highly developed region with many advanced healthcare infrastructures. Government has taken up initiatives to formulate many reimbursement policies that can be helpful to patients. All of these factors are increasing the market growth.

KEY INDUSTRY PLAYERS

Leading Players adopt Acquisition Strategies to Stay Competitive

Several players in the market are using acquisition strategies to build their business portfolio and strengthen their market position. In addition, partnerships and collaborations are among the common strategies adopted by companies. Key market players are making R&D investments to bring advanced technologies and solutions to the market.

List of Top Overt Hepatic Encephalopathy Companies

  • Alfa Wassermann (U.S.)
  • Cosmo Pharmaceuticals (Ireland)
  • Horizon Pharma (U.S.)
  • KannaLife Sciences (U.S.)
  • Ocer Therapeutics (U.S.)
  • Rebiotix (U.S.)
  • Spherium Biomed (Spain)
  • Umecrine Cognition (Sweden)
  • ASKA Pharmaceutical (Japan)
  • Mallinckrodt (U.K.)
  • Valeant(Canada)

REPORT COVERAGE

The report provides an insight into the industry from both the demand and supply sides. Further, it also gives information on the impact of COVID-19 on the market, the driving and the restraining factors along with the regional insights. Market dynamic forces during the forecast period have also been discussed for the better understanding of the market situations. The top industrial players along with the region that dominates the market has also been given for the readers to know.

Overt Hepatic Encephalopathy Market Report Scope & Segmentation

Attributes Details

Market Size Value In

US$ 0.05 Billion in 2024

Market Size Value By

US$ 0.11 Billion by 2033

Growth Rate

CAGR of 6.4% from 2025 to 2033

Forecast Period

2025-2033

Base Year

2024

Historical Data Available

Yes

Regional Scope

Global

Segments Covered

By Type

  • Type A (Acute Liver Failure)
  • Type B (Portal Systemic Bypass Without Liver Disease)
  • Type C (Liver Cirrhosis)

By Application

  • Hospitals
  • Research Institutes
  • Clinics
  • Others

FAQs