Size Exclusion Chromatography (SEC) HPLC Column Market Size, Share, Growth, And Industry Analysis, By Type (ID Below 4.6mm, ID 4.6-7.8mm and ID Above 7.8mm), By Application (Pharmaceutical and Biotech Company, Academic & Research Institutions and Others), and Regional Forecast From 2025 To 2033

• 

  Request a Free sample to learn more about this report

SIZE EXCLUSION CHROMATOGRAPHY (SEC) HPLC COLUMN MARKET OVERVIEW

The global Size Exclusion Chromatography (SEC) HPLC Column Market, valued at USD 0.56 billion in 2024, is projected to grow steadily to USD 0.61 billion in 2025 and reach USD 1.21 billion by 2033, maintaining a CAGR of 8.8% from 2025 to 2033.

By separating and analyzing molecules according to their size or molecular weight, size exclusion chromatography (SEC) is a type of liquid chromatography. This method uses a stationary phase of porous beads with a specified pore size distribution, and SEC HPLC columns are columns specifically made for this method. In many different applications, including protein analysis, polymer analysis, and quality monitoring of biological products, size exclusion chromatography (SEC) HPLC columns are frequently used.

The market for size exclusion chromatography (SEC) HPLC columns is expanding as a result of the rising demand in the biopharmaceutical and life sciences sectors for effective and dependable separation methods. The study of biomolecules including proteins, peptides, and nucleic acids is frequently carried out using SEC HPLC columns, which is why these columns are crucial for drug development and quality control. The SEC HPLC column sector is expanding as a result of technological developments such the creation of better resins and columns with higher resolution and sensitivity.

SIZE EXCLUSION CHROMATOGRAPHY (SEC) HPLC COLUMN MARKET SHARE FACTS AND FIGURES

Regional Breakdown

• North America holds a 40% market share (USD 0.224 billion) with a 8.5% CAGR. Growth is driven by advancements in pharmaceutical and biotechnology sectors, with increasing demand for HPLC columns for high-resolution separations in drug development and quality control.

• Asia-Pacific holds a 35% share, equating to USD 0.196 billion in 2024, with a growth rate of 9.2% CAGR. The region’s growth is driven by the expanding pharmaceutical industry and increasing adoption of analytical instruments in countries like China, Japan, and India.

• Europe holds 15% of the market, primarily in Germany, France, and the UK, with a 7.8% CAGR. Growth is due to the rising demand for SEC HPLC columns in research, diagnostics, and the rapidly growing biotech industry.

• Rest of the World holds around 10% of the global market, amounting to USD 0.056 billion in 2024, with a growth rate of 8.0% CAGR. This growth is mainly observed in Latin America and the Middle East, where healthcare advancements are driving the need for high-performance analytical tools.

Product Segments Breakdown

• ID Below 4.6mm dominates the market with approximately 50% of sales, amounting to about USD 0.28 billion in 2024, growing at a 8.7% CAGR. This segment is popular in high-precision applications, including protein analysis and purification in pharmaceutical industries.

• ID 4.6-7.8mm holds around 35% of the market, or about USD 0.196 billion in 2024, growing at 8.5% CAGR. These columns are widely used in routine analytical separations and are favored in research labs.

• ID Above 7.8mm holds around 15% of the market, or about USD 0.084 billion in 2024, growing at 9.2% CAGR. Larger columns are typically used for preparative separations in industrial applications.

COVID-19 IMPACT

Disruption of the Supply Chain Resulted in Shortage of Raw Materials 

Many unfavorable effects of the COVID-19 epidemic have been observed in the HPLC column industry. The disruption of the global supply chain caused by production facility closures and transit limitations, which resulted in a shortage of raw materials and delivery delays, was one of the biggest problems the market faced. Due to the large price increase brought on by this, some end users were no longer able to afford SEC HPLC columns. At several organizations, budget cuts as a result of the pandemic's economic uncertainties reduced their capacity to fund research and development, including the acquisition of these columns.

LATEST TRENDS

Using High-performance Columns with Enhanced Sensitivity for Less Frequent Replacements

The growing use of high-performance columns with increased resolution and sensitivity is one of the most recent trends in the size exclusion chromatography (SEC) HPLC column industry. In order to deliver better resolution and quicker analysis times, manufacturers are investing in R&D to create SEC HPLC columns with cutting-edge materials, enhanced particle sizes, and improved pore size distributions. These columns are also intended to be stronger and more resilient, resulting in longer lifespans and less frequent replacement. In general, the newest advancements in the SEC HPLC Column market are concentrated on providing more efficient and reliable analysis of complex biomolecules with improved resolution, sensitivity, and automation.

Request a Free sample to learn more about this report

SIZE EXCLUSION CHROMATOGRAPHY (SEC) HPLC COLUMN MARKET SEGMENTATION

By Type Analysis

According to type, the market can be segmented into ID Below 4.6mm, ID 4.6-7.8mm and ID Above 7.8mm

By Application Analysis

Based on application, the market can be divided into Pharmaceutical and Biotech Company, Academic & Research Institutions and Others

DRIVING FACTORS

HPLC Industry is Being Driven by the Developing Biopharmaceutical Sector

Due to the rising need for innovative medicines and personalized medicine, the biopharmaceutical business is expanding significantly. For the analysis and quality control of biomolecules used extensively in the biopharmaceutical sector, such as proteins, peptides, and nucleic acids, SEC HPLC columns are crucial. As a result, one of the key factors propelling the market for size exclusion chromatography (SEC) HPLC columns is the expansion of the biopharmaceutical sector.

Increased Emphasis on R&D Due to Rising Demand for Personalized Medication

The need for SEC HPLC columns is being fueled by the increased emphasis on research and development across a variety of sectors, including pharmaceuticals, biotechnology, and life sciences. Complex biomolecules are frequently utilized in research and development, making these columns crucial for the study and purification of these substances. A more sophisticated size exclusion chromatography (SEC) HPLC column is required in order to handle complex biomolecules with greater sensitivity and resolution, which is driven in part by the growing need for customized medicine and precision healthcare.

RESTRAINING FACTORS

High Cost Involved with the Columns Might Hinder the Expansion of the Industry

The high cost involved with the development, production, and acquisition of these products is a significant restraint on the size exclusion chromatography (SEC) HPLC column market growth. Specialized materials and methods are needed, together with extensive R&D and quality control efforts, for the manufacture of the columns. The price of HPLC columns is also increased by the high cost of raw materials and manufacturing tools. Generally speaking, the high price of SEC columns is a significant market restraint as it might prevent adoption and expansion, especially in price-sensitive market groups.

• Request a Free sample to learn more about this report

•  

SIZE EXCLUSION CHROMATOGRAPHY (SEC) HPLC COLUMN MARKET REGIONAL INSIGHTS

Well Established Pharmaceutical and Biotechnology Sectors are Driving the Regional Market

In terms of revenue and demand, North America is anticipated to rule the size exclusion chromatography (SEC) HPLC column market share throughout the projected timeline. This is explained by the presence of numerous important companies in the area, considerable R&D expenditures, and an increase in the demand for cutting-edge treatments and personalized medicine. Furthermore, the region's well-established pharmaceutical and biotechnology sectors are what are driving the demand for HPLC columns for R&D projects and quality assurance of biopharmaceuticals. Demand for SEC columns in the area is also anticipated to increase as a result of the growing emphasis on precision medicine and the creation of cutting-edge treatments such as cell and gene therapies.

KEY INDUSTRY PLAYERS

Key Players Focus on Alliances and Mergers to Grow their Market Positions

Businesses in the size exclusion chromatography (SEC) HPLC column are forming alliances with other significant market participants to broaden their product offering and delivery system. These alliances can give businesses access to new markets and clients, enable them to offer a wider range of products, and give them a competitive edge. To grow their market position and share, several businesses are now partaking in mergers and acquisitions. Companies can acquire new technology, product lines, and customer bases through acquisitions, which can aid them in achieving their growth goals.

List of Top Size Exclusion Chromatography (SEC) HPLC Column Companies

• Agilent Technologies (U.S.)
• Waters Corporation (U.S.)
• Shimadzu (Japan)
• Tosoh Corporation (Japan)
• Thermo Fisher Scientific (U.S.)
• Danaher (U.S.)
• Bio-Rad (U.S.)
• Merck (Germany)

REPORT COVERAGE

This report covers the size exclusion chromatography (SEC) HPLC column market. The CAGR expected to be in during the forecast period, and also the USD value in 2021 and what it is expected to be in 2028. The effect COVID-19 had on the market in the beginning of the pandemic. The latest trends taking place in this industry. The factors that are driving this market as well as the factors that are restraining the growth of industry. The segmentation of this market based on type and applications. The region leading in the industry and why they will continue to do so during the forecast period. Further, the key market players, what all is being done by them to stay ahead of their competition as well as retain their market positions. All these details are covered in the report.