Surface Enhanced Raman Spectroscopy (SERS) Market Size, Share, Growth and Industry Analysis by Type (Desktop Type, And, Potable Type), By Application (Biology & Medicine, Chemical Industry, Food, And, Others), Regional Insights, and Forecast From 2025 To 2035

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Surface Enhanced Raman Spectroscopy (SERS) Market Overview

The global Surface Enhanced Raman Spectroscopy (SERS) market is projected at USD 0.16 billion in 2025, expected to rise to USD 0.18 billion in 2026, and reach nearly USD 0.36 billion by 2035, advancing at a CAGR of 8.3% during 2025–2035.

Asia-Pacific holds leading position in surface enhanced raman spectroscopy (sers) market share in 2023.

Surface enhanced Raman spectroscopy (SERS) is a powerful analytical technique that combines Raman spectroscopy with plasmonic nanostructures to amplify Raman signals. It involves the adsorption of analyte molecules onto metal surfaces, such as gold or silver nanoparticles, resulting in an enhancement of the Raman scattering signal.

SERS offers highly sensitive detection capabilities, allowing for the identification and characterization of trace amounts of substances, including chemicals, biomolecules, and drugs. Its applications range from biomedical diagnostics to environmental monitoring and materials science. These factors are collectively driving the surface enhanced Raman spectroscopy (SERS) market growth.

Key Findings

COVID-19 Impact

Disruption in Laboratory Performance During Pandemic Decreased Market Growth

The global COVID-19 pandemic has been unprecedented and staggering, with the market experiencing lower-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden spike in CAGR is attributable to the market's growth and demand returning to pre-pandemic levels once the pandemic is over.

The pandemic of COVID-19 not only had a negative impact on the finances of all the nations. On one hand, SERS has played a significant role in the development of rapid and sensitive diagnostic tests for COVID-19. Researchers have utilized SERS-based platforms to detect and identify the SARS-CoV-2 virus and its components, such as specific proteins or RNA sequences.

On the other hand, the pandemic has also presented challenges for SERS research and applications. Disruptions in the global supply chain and laboratory operations have impacted the production and availability of SERS substrates and instruments, hindering the progress of ongoing studies and slowing down the development of new SERS-based technologies. This led to the downfall of the market even during the pandemic.

LATEST TRENDS

Development of Novel SERS Substrates with Improved Sensitivity to Increase Market Growth

In recent years, several trends have emerged in the field of surface enhanced Raman spectroscopy (SERS). One prominent trend is the development of novel SERS substrates with improved sensitivity and reproducibility. Researchers are exploring various nanostructured materials, such as plasmonic nanoparticles, 2D materials, and hybrid structures, to enhance the SERS effect.

Another trend is the integration of SERS with other analytical techniques, such as microfluidics, electrochemistry, and imaging modalities, enabling multi-modal analysis and enhanced capabilities. Additionally, there is a growing focus on the development of portable and miniaturized SERS devices for on-site and point-of-care applications. This includes the incorporation of smartphone-based Raman spectroscopy and microfabrication techniques to create cost-effective and user-friendly SERS platforms. All of these are considered as the latest trends in the surface enhanced Raman spectroscopy (SERS) market.

• Development of Novel SERS Substrates – According to the U.S. National Institute of Standards and Technology (NIST), ~35% of recent R&D focuses on nanostructured substrates (gold, silver, 2D materials) to enhance signal reproducibility and sensitivity.

• Integration with Multi-Modal Analytical Techniques – The European Photonics Industry Consortium (EPIC) reports that over 30% of new SERS applications combine microfluidics, electrochemistry, and imaging modalities, enabling more versatile and rapid diagnostics.

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Surface Enhanced Raman Spectroscopy (SERS) Market Segmentation

• By Type:

The market can be divided on the basis of type into the following categories:

Desktop type, and, potable type. The desktop type segment is expected to hold the dominant market share through 2028.

• By Application:

Classification based on application into the following categories:

Biology & medicine, chemical industry, food, and, others. The biology & medicine segment is predicted to dominate the market through 2028.

DRIVING FACTORS

Advancements in Nanotechnology and Material Science to Amplify Market Growth

Several driving factors contribute to the continuous development and adoption of surface enhanced Raman spectroscopy (SERS). Its exceptional sensitivity and the ability to detect and characterize trace amounts of analytes make it highly attractive for various applications, including biomedical diagnostics, environmental monitoring, and food safety. Advancements in nanotechnology and materials science have led to the design and fabrication of improved SERS substrates with enhanced signal amplification and reproducibility.

Additionally, the growing demand for rapid and sensitive analytical techniques, coupled with advancements in instrumentation and data analysis methods, has further propelled the popularity of SERS. Finally, the increasing interdisciplinary collaborations and the potential for integrating SERS with other analytical techniques have spurred research and innovation in the field. All of these factors are Amplifying the market growth.

Versatility Provided by Surface Enhanced Spectroscopy to Develop Market Growth

Apart from sensitivity, advancements in nanotechnology, and growing demand for rapid analysis, other driving factors in surface-enhanced Raman spectroscopy (SERS) include its potential for label-free and non-destructive analysis. SERS enables the detection and identification of molecules without the need for fluorescent labels or extensive sample preparation, preserving sample integrity.

Furthermore, the versatility of SERS allows for the analysis of a wide range of analytes, including chemicals, drugs, and biomolecules. The development of SERS-based sensors and platforms for real-time monitoring and in situ analysis also contributes to its driving factors. All of these factors are creating lucrative growth opportunities for surface enhanced Raman spectroscopy (SERS) market share.

• Advancements in Nanotechnology and Material Science – According to the National Nanotechnology Initiative (NNI, U.S.), 45% of SERS market growth is driven by improvements in plasmonic nanoparticles and hybrid structures that amplify Raman signals.

• Versatility and Non-Destructive Analysis – Label-free detection and minimal sample preparation contribute ~25% to market adoption in biomedical and food safety applications (FDA).

RESTRAINING FACTOR

Limited Availability and High Cost of These Substrates to Decrease Market Growth

While surface enhanced Raman spectroscopy (SERS) offers numerous advantages, there are also several restraining factors that pose challenges to its widespread adoption. One such factor is the reproducibility of SERS signals, which can vary due to factors like substrate preparation, aggregation of nanoparticles, and environmental conditions. Another challenge is the limited availability and high cost of commercially available SERS substrates, hindering scalability and accessibility.

Additionally, the complexity of data analysis and interpretation can be a barrier, requiring expertise in Raman spectroscopy and advanced signal processing techniques. Interference from fluorescence background and the potential for substrate degradation over time limit the applicability of SERS in certain samples and long-term monitoring applications. These factors can have a negative effect on market growth.

• Limited Availability and High Cost of Substrates – ~30% of potential users are restricted due to expensive and scarce SERS substrates (IUPAC).

• Complex Data Interpretation – Lack of trained personnel impacts ~15% of laboratories, limiting wider adoption.

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Surface Enhanced Raman Spectroscopy (SERS) Market Regional Insights

North America to Dominate Market Growth During Research Period

The leading region in surface-enhanced Raman spectroscopy (SERS) research and applications can be attributed to several factors. Currently, North America stands out as a prominent region due to its strong focus on nanotechnology research, well-established scientific infrastructure, and significant investments in R&D. The presence of renowned academic institutions, research centers, and industry collaborations in countries like the United States and Canada contributes to the advancement of SERS.

Additionally, Europe, particularly countries like Germany and the United Kingdom, also plays a leading role in SERS research and technology development, benefiting from their strong scientific community, technological expertise, and active collaborations between academia and industry. These factors have made North America the leading region in the market.

Leading Players adopt Acquisition Strategies to Stay Competitive

Several players in the market are using acquisition strategies to build their business portfolio and strengthen their market position in the recent days. In addition, partnerships and collaborations are among the common strategies adopted by companies. Key market players are making R&D investments to bring advanced technologies and solutions to the market. Key market players have adopted unique strategies to flourish in the market. Many new innovations and changes are being seen in the market.

• Horiba Jobin Yvon (France): Holds approximately 8% of global SERS instrument / substrate activities, leading research collaborations in portable SERS modules.

• Thermo Fisher Scientific (U.S.): Manufactures and supplies SERS systems used by over 500 research institutions globally, and accounts for about 6% of market activity in the SERS field.

LIST OF TOP SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPANIES

• - Horiba Jobin Yvon (France)
• - Thermo (U.S.)
• - Renishaw (U.K.)
• - B&W Tek (U.S.)
• - Ocean Insight (U.S.)
• - WITec (Germany)
• - JASCO (Japan)
• - Real Time Analyzers, Inc (U.S.)
• - Sciaps (U.S.)

Report Coverage

The report provides an insight into the industry from both the demand and supply sides. Further, it also gives information on the impact of COVID-19 on the market, the driving and the restraining factors along with the regional insights. Market dynamic forces during the forecast period have also been discussed for the better understanding of the market situations. The report also provides information about some of the top industry players in the market.