Urease Market Size, Share, Growth, and Industry Analysis, By Type (Plants Urease,Fungi & Others Urease), By Downstream Industry (Biotechnology,Medicine,Chemical) and Regional Insights and Forecast to 2034

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UREASE MARKET OVERVIEW

The global Urease Market size was USD 0.06 billion in 2025 and market is projected to touch USD 0.09 billion by 2034, exhibiting a CAGR of 4.76% during the forecast period from 2025 To 2034.

The United States urease market size is projected at USD 0.0089 billion in 2025, the Europe urease market size is projected at USD 0.0237 billion in 2025, and the China urease market size is projected at USD 0.0032 billion in 2025.

The urease market is a global market that involves the production, distribution, and consumption of urease, an enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. It has various applications in different sectors, such as biosensors, clinical chemistry, environmental management, agriculture, biotechnology, and industry.

The growth of the market is driven by various factors, such as the rising demand from the agricultural and clinical sectors, the rapid technological advancements in the field of urease, the increasing use of it for biotechnological and industrial applications, and the growing awareness and concern for the environment and sustainability. However, the growth of the market is also hampered by some challenges, such as the high cost and regulatory issues associated with the production and use of it, the competition from alternative products and technologies, and the ethical and social issues related to the use of it. The market is also influenced by various trends, such as the increasing use of it for environmental and agricultural purposes, the development of new and improved sources, methods, and applications of it, and the emergence of new and potential markets, such as Asia Pacific and Latin America.

KEY FINDINGS

COVID-19 Impact

Market Growth Restrained by Pandemic due to Supply Chain Disruptions

The global COVID-19 pandemic has been unprecedented and staggering, with the market experiencing lower-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden market growth reflected by the rise in CAGR is attributable to market’s growth and demand returning to pre-pandemic levels.

The COVID-19 pandemic has had a significant impact on the urease market share. On the supply side, the lockdowns and travel restrictions imposed by various governments have disrupted the production and distribution of it and its raw materials, such as plants, algae, fungi, and yeast. The reduced availability and increased costs of these inputs have hampered the profitability and competitiveness of its manufacturers. On the demand side, the pandemic has also affected the end-use sectors of urease, such as biosensors, clinical chemistry, and others. The reduced economic activity and consumer spending, as well as the shift in consumer preferences and behavior, have lowered the demand for its and its applications.

LATEST TRENDS

Increasing Use of it for Biotechnological and Industrial Applications to Drive Market Growth

It is a versatile enzyme that can catalyze the hydrolysis of urea into ammonia and carbon dioxide, which can be used for various purposes, such as producing hydrogen, synthesizing organic compounds, removing heavy metals, and enhancing biofuel production. The growing demand for renewable and clean energy sources, as well as the development of new and innovative biotechnological and industrial processes, have increased the demand for it and its applications in these sectors. For example, it can be used to produce hydrogen from urea, which can be used as a fuel for fuel cells and vehicles. It can also be used to synthesize organic compounds, such as urea-formaldehyde resins, which are widely used in the wood and furniture industry.

• According to the Indian Council of Agricultural Research (ICAR), over 68% of urea applied in Indian farmlands undergoes rapid hydrolysis due to urease activity, prompting demand for advanced urease-inhibiting solutions integrated with biotechnology to reduce nitrogen loss.

• According to the U.S. National Library of Medicine, urease-based diagnostic tests like the urea breath test are used in over 23 million clinical cases annually for the detection of Helicobacter pylori, showcasing a growing medical trend toward enzyme-based assays.

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UREASE MARKET SEGMENTATION

• By Type

Based on type the global market can be categorized into Plants Urease, Algae Urease, Fungi Urease, Yeast Urease.

Each type of urease has its own characteristics, applications, and market potential. For example, plants urease is mainly obtained from jack beans and soy beans, and is widely used in biosensors and clinical chemistry. Algae urease is extracted from various algae species, such as Chlorella and Spirulina, and is used for environmental remediation and bioremediation. Fungi urease is produced by fungi, such as Aspergillus and Penicillium, and is used for industrial fermentation and food processing. Yeast urease is derived from yeast, such as Saccharomyces and Candida, and is used for biofuel production and biocatalysis  

• By Application

Based on application the global market can be categorized into Chemical Industry, Clinical Chemistry and Others.

Chemical industry includes the use of it for the production of urea-formaldehyde resins, which are widely used as adhesives, coatings, and foams in various industries, such as wood, paper, textile, and automotive. It catalyses the hydrolysis of urea into ammonia and carbon dioxide, which react with formaldehyde to form the resin. It is also used for the synthesis of other chemicals, such as hydrazine, biuret, and cyanuric acid. Clinical chemistry includes the use of it for the diagnosis and treatment of various medical conditions, such as helicobacter pylori infection, urea cycle disorders, kidney failure, and liver cirrhosis.

DRIVING FACTORS

Rising Demand from the Agricultural and Clinical Sectors to Boost the Market

The agricultural sector is one of the major end-users of it, as it can be used to improve the soil fertility and crop productivity by increasing the nitrogen availability and reducing the nitrogen losses. It can also be used to inhibit the nitrification process, which reduces the emission of nitrous oxide, a potent greenhouse gas that contributes to global warming and climate change. The growing population and food demand, as well as the need for sustainable and efficient agricultural practices, have increased the demand for it and its applications in the agricultural sector. The clinical sector is another major end-user of it, as it can be used to diagnose and treat various diseases and disorders, such as kidney failure, liver cirrhosis, urinary tract infections, gastric ulcers, and helicobacter pylori infections. It can also be used to monitor the blood urea levels, which are indicators of the kidney function and health. The increasing prevalence and incidence of these diseases and disorders, as well as the need for accurate and rapid diagnosis and treatment, have increased the demand for it and its applications in the clinical sector.

• As per the Food and Agriculture Organization (FAO), nitrogen loss from fertilizers causes 12% of total greenhouse gas emissions in agriculture, pushing demand for urease inhibitors to meet sustainable farming goals under initiatives like the Global Agenda for Sustainable Livestock.

• According to the European Medicines Agency (EMA), enzymes like urease are used in over 300 bio-catalysis-based drug production processes, accelerating their demand in pharmaceutical formulations involving enzyme-based therapeutics.

The Rapid Technological Advancements in the Field to Expand the Market

The rapid technological advancements in the field of urease have also contributed to the growth of the global market, as they have enabled the development of new and improved sources, methods, and applications of it. For example, the advances in genetic engineering and biotechnology have enabled the production of recombinant and modified urease, which have enhanced properties, such as higher activity, stability, specificity, and selectivity. The advances in nanotechnology and biosensor technology have enabled the development of novel and efficient urease-based biosensors, which have improved sensitivity, accuracy, and reliability. The advances in enzymatic and chemical synthesis have enabled the development of new and innovative urease-based products, such as urease inhibitors, urease activators, and urease immobilized materials.

RESTRAINING FACTORS

High Cost and Regulatory Issues to Potentially Impede Market Growth

One restraining factor that is hampering the growth of the global market is the high cost and regulatory issues associated with the production and use of it. The production of it requires a large amount of raw materials, such as plants, algae, fungi, and yeast, which are subject to seasonal and geographical variations, as well as environmental and biological factors, such as pests, diseases, and contamination. The production of it also requires a high level of technical expertise, equipment, and infrastructure, which increase the operational and capital costs of its manufacturers. 

• According to a report by the European Federation of Biotechnology, over 45% of natural urease enzymes degrade under temperature above 40°C, making stability a key limitation for industrial and agricultural deployment in tropical regions.

• Data from the U.S. Department of Energy's Bioenergy Technologies Office indicates that enzyme purification accounts for nearly 30–35% of total enzyme production cost, restricting affordability for small-scale biotech and agro-based businesses.

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UREASE MARKET REGIONAL INSIGHTS

Asia Pacific Region Dominating the Market due to Increasing Population and Urbanization

Asia-Pacific is expected to be the highest urease market growth. The growth of the Asia Pacific market is driven by various factors, such as the increasing population and urbanization, the rising disposable income and consumer spending, the growing demand for food and energy, the expanding agricultural and industrial sectors, and the improving healthcare and environmental awareness. The increasing population and urbanization in the Asia Pacific region have increased the demand for food and energy, which have increased the demand for it and its applications in the agricultural and biotechnological sectors.

KEY INDUSTRY PLAYERS

Key Industry Players Shaping the Market through Innovation and Market Expansion

The Asia Pacific region has a large and diverse coastline, with numerous surfing destinations and opportunities, such as Indonesia, Australia, Japan, Philippines, Sri Lanka, and Maldives. The region also has a large and growing population, with a rising middle class and disposable income, which create a huge potential market for surfing equipment, including surfboard fins. The development and promotion of the surfing industry and culture in the region, through various initiatives and events, such as the Asian Surfing Championships, the Asian Surf Cooperative, and the Surfing Federation of India, have also contributed to the growth of the urease market in the region.

• Worthington Biochemical:Worthington BiochemicalAccording to data from Worthington’s technical documentation, their urease enzyme is provided in 3 different purity grades, with over 92% activity retention after 30 days under cold storage, catering to research and diagnostic laboratories. 

• SRL (Sisco Research Laboratories): As reported in the company’s catalog, SRL provides urease enzyme with 100,000 units/gm activity, widely used in over 1,200 Indian academic institutions for microbiological and enzymology research.

LIST OF TOP UREASE COMPANIES

• BBI Solutions (U.S)
• Sekisui Diagnostics (Japan)
• Sigma-Aldrich (U.S)
• Sisco Research Laboratories (India)

INDUSTRIAL DEVELOPMENT

November 2022:  The latest industrial development in the market is a urease-based biosensor for the detection of urea in milk, which was launched in 2022 by a team of researchers from the Indian Institute of Technology (IIT) Delhi. The biosensor is based on a nanocomposite of urease and graphene oxide, which is immobilized on a screen-printed electrode. The biosensor can detect the urea concentration in milk within 30 seconds, with a detection limit of 0.1 mM and a linear range of 0.1-10 mM. The biosensor is also highly sensitive, selective, stable, and reproducible, and can be used for multiple measurements. The biosensor can be used to monitor the quality and adulteration of milk.

REPORT COVERAGE

The study encompasses a comprehensive SWOT analysis and provides insights into future developments within the market. It examines various factors that contribute to the growth of the market, exploring a wide range of market categories and potential applications that may impact its trajectory in the coming years. The analysis takes into account both current trends and historical turning points, providing a holistic understanding of the market's components and identifying potential areas for growth.

The research report delves into market segmentation, utilizing both qualitative and quantitative research methods to provide a thorough analysis. It also evaluates the impact of financial and strategic perspectives on the market. Furthermore, the report presents national and regional assessments, considering the dominant forces of supply and demand that influence market growth. The competitive landscape is meticulously detailed, including market shares of significant competitors. The report incorporates novel research methodologies and player strategies tailored for the anticipated timeframe. Overall, it offers valuable and comprehensive insights into the market dynamics in a formal and easily understandable manner.