Digital PCR Market Size, Share, Growth, and Industry Analysis, By Type (Microreactor/Orifice Plate Digital PCR, Microfluidic Chip Digital PCR and Droplet Digital PCR), By Application (Early Study of Tumor, Quantitative Analysis of A New Generation Sequencing Library, Gene Expression Analysis, Pathogen Detection, Prenatal Diagnosis and Other) and Regional Insight and Forecast to 2033

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DIGITAL PCR MARKET REPORT OVERVIEW

The digital pcr market, valued at approximately USD 5.66 billion in 2024, is forecasted to grow consistently, reaching USD 6.16 billion in 2025 and ultimately achieving USD 12.09 billion by 2033, at a steady CAGR of about 8.88%.

Quantitative PCR (qPCR) is a sophisticated molecular biology method that serves to estimate the number of nucleic acids, for example DNA or RNA. In contrast to what can be obtained in traditional PCR, the accuracy of which is based on the amplification curves obtained, dPCR does not require the use of standard calibrations or reference curves, while offering absolute quantification.

COVID-19 IMPACT

Digital PCR Industry Had a Positive Effect Due to Increased Demand for Accurate Diagnostics during COVID-19 Pandemic

The global COVID-19 pandemic has been unprecedented and staggering, with the market experiencing higher-than-anticipated demand across all regions compared to pre-pandemic levels. The sudden market growth reflected by the rise in CAGR is attributable to market’s growth and demand returning to pre-pandemic levels.

The rationale for accurate and quantitative detection of SARS-CoV-2 RNA increased the use of  PCR because of its higher sensitivity and specificity as compared to qPCR dPCR was useful to generate low viral load asymptomatic carriers and useful in tracking viral evolution.

LATEST TRENDS

Integration with Next-Generation Sequencing (NGS) to Propel Market Growth

The integration with Next Generation Sequencing (NGS) is starting to become one of the growth trends in the dPCR market, improving the functions of both systems. While the dPCR has a great capability to measure nucleic acid amounts and to detect the low frequency of mutations, the NGS offer a whole-genome sequencing data. Integration of these technologies gives the researchers the opportunity to get the maximum of accuracy and detail in molecular analysis.

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DIGITAL PCR MARKET SEGMENTATION

By Type

Based on type the market can be categorized into Microreactor/Orifice Plate Digital PCR, Microfluidic Chip Digital PCR and Droplet Digital PCR.

• Microreactor/Orifice Plate Digital PCR- The sample is subdivided in to individual wells on a microplate or microreactor and a distribution orifice plate is used in most cases.

• Microfluidic Chip Digital PCR- Clinical methods employ microfluidic chips with the partitions prepared in advance and allowing the division of the sample into the thousands of nanoliter volumes of chambers.

• Droplet Digital PCR- In the sample, the sample is dispersed into thousands to millions of small droplets, where every particle of the droplets behaves as a single reactor.

By Application

Based on application the market can be categorized into Early Study of Tumor, Quantitative Analysis of A New Generation Sequencing Library, Gene Expression Analysis, Pathogen Detection, Prenatal Diagnosis and Other.

• Early study of Tumor- dPCR is used for cancer diagnosis and prognosis because it provides information about the amount of ctDNA or particular genetic changes in a blood or tissue test.

• Quantitative Analysis of A New Generation Sequencing Library- dPCR is applied to measure the amount of NGS libraries to ensure high density and efficient cluster generation.

• Gene Expression Analysis- The absolute quantification of gene expression levels is feasible in low-abundance transcripts and the samples with high noise levels using the dPCR.

• Pathogen Detection- dPCR is commonly employed to identify and measure viral, bacterial or fungal pathogens without interference from other Koch samples with low pathogen concentrations.

• Prenatal Diagnosis- Another prenatal diagnostic technique that dPCR enhances is the non-invasive diagnostics of fetal genetic disorders through the analysis of cffDNA in the mother’s blood.

Driving Factors

Increasing Demand for Precision Medicine to Drive Market Advancement

One of the key driving factors in the Digital PCR market growth is Increasing Demand for Precision Medicine. One of the major growth drivers for the digital PCR (dPCR) market is the growing trend for precision medicine since this kind of medical approach needs accurate diagnostic procedures to design specific treatment strategies. Precision medicine uses the knowledge of genetic, molecular and environmental characteristics of a person to individualize treatment approaches particularly for cancer, rare genetic conditions, and long-term health conditions.

Rising Prevalence of Genetic and Infectious Diseases to Expand the Market

One of the key reasons for market growth is the increased incidence of hereditary and infectious diseases, which requires the use of accurate quantitative PCR methods, digital (dPCR). Diseases like cystic fibrosis, Huntington’s disease and some hereditary cancers that needs accurate measurement technique for mutations, copy number variations or any other genetic element.

Restraining Fcator

High Cost of Instruments and Consumables Poses Potential Impediments to Market Growth

The adoption of digital PCR (dPCR) is currently restricted due to the high costs of instruments and consumables which is an influential market restraint in many developed and developing nations. However, one must consider not only the first-time investment in dPCR equipment but also additional consumables which amplify its price – reagents, microfluidic chips, etc.

Opportunity

Advancements in Technology and Automation To Create Opportunity for the Product in the Market

Technological enhancement and automation are staking major growth in the dPCR market by bringing the technology closer, productive, and adaptable. In the past, dPCR systems were characterized by high operational complexity and the need for professional personnel to perform both the experiment and the analysis of the results. But with the advancement in automation and integration, these processes are no longer complex, thereby reducing the stress of training in the usage of dPCR systems.

Challenge

Complexity in Data Analysis and Interpretation Could Be a Potential Challenge for Consumers

Digital PCR generates much data which is often analyzed using highly complex computation and skills. Logging of the results is also convenient, although data interpretation can be problematic, particularly for complex assays or when confronted with rare mutations. Their requirements and data processing nature make dPCR more desirable for specialized areas, rather than general application, particularly in centers where they do not have bioinformaticians or data specialists.

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DIGITAL PCR MARKET REGIONAL INSIGHTS

•  North America

North America has emerged as the most dominant region in the Digital PCR market share due to a convergence of factors that propel its leadership in this dynamic industry. The regions that dominate the digital PCR market are North America, especially the United States. This is because of increased spending on healthcare research, biotechnology and molecular diagnostic, leading life science companies and academic institutions.

•  Europe

Another region that also contributes largely to the dPCR market is the European nations particularly Germany, UK and France using digital PCR usually in research with diagnostic facilities. The region has good accesses to health care facilities, CE marking for regulation and emphasis on genomic medicine.

• Asia

Asia pacific is expected to the most rapidly growing region in the midst of the following years. Although at present it occupies a significantly less share compared to North America and Europe due to growing investments in healthcare, rising awareness of precision medicine and increasing demand for genetic diagnosis, it is experiencing substantial growth.

KEY INDUSTRY PLAYERS

Key Players Transforming the Digital PCR Landscape through Innovation and Global Strategy

Key enterprise players are shaping the Digital PCR marketplace through strategic innovation and marketplace growth. The market leaders in the dPCR market are outsourcing their services and technologies to academic institutions, research organizations, and healthcare companies. The companies in the field are endeavoring to come out with better dPCR technologies in terms of sensitivity, multiplexing and automation and capabilities to analyze the generated data.

List of Top Digital Pcr Companies

• F. Hoffman-LA Roche Ltd. (Switzerland)
• Qiagen N.V. (Germany)
• Bio-Rad Laboratories, Inc. (U.S.)
• Thermo Fisher Scientific, Inc. (U.S.)
• Agilent Technologies, Inc. (U.S.)

INDUSTRIAL DEVELOPMENT

Mar 2022: Stilla Technologies, a startup Swedish life science technology company, recently declared a new project, where it is to receive USD 31.3 million from the European Investment Bank. The project therefore aims at enhancing the improvement of next generation kinds of genetic tests by presenting an exceptional and versatile platform.

REPORT COVERAGE

The study encompasses a comprehensive SWOT analysis and provides insights into future developments within the market. It examines various factors that contribute to the growth of the market, exploring a wide range of market categories and potential applications that may impact its trajectory in the coming years. The analysis takes into account both current trends and historical turning points, providing a holistic understanding of the market's components and identifying potential areas for growth.

The research report delves into market segmentation, utilizing both qualitative and quantitative research methods to provide a thorough analysis. It also evaluates the impact of financial and strategic perspectives on the market. Furthermore, the report presents national and regional assessments, considering the dominant forces of supply and demand that influence market growth. The competitive landscape is meticulously detailed, including market shares of significant competitors. The report incorporates novel research methodologies and player strategies tailored for the anticipated time frame. Overall, it offers valuable and comprehensive insights into the market dynamics in a formal and easily understandable manner.